A Powerful Innovation for Improving Egg Quality

Cytoplasmic Transfer — also known as Mitochondrial Transfer — is an advanced technique used to improve the quality and fertilization potential of a woman’s eggs. It offers new hope for women with diminished ovarian reserve or those who have experienced repeated IVF failures due to poor egg quality.

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What is Cytoplasmic (Mitochondrial) Transfer?

Every human cell contains mitochondria — tiny, powerful structures often referred to as the cell’s “energy factories.”They are essential for healthy cell division, embryo development, and successful fertilization.

In this technique, mitochondria from a healthy donor egg (usually from a young, fertile woman) are transferred into the patient’s egg before fertilization. This boost in mitochondrial energy can significantly enhance the egg’s performance — increasing the chances of successful fertilization, embryo development, and pregnancy.

Studies show that mitochondrial transfer may raise success rates up to 60% in eligible cases.

Who Can Benefit from Cytoplasmic Transfer?

This treatment is especially recommended for women who:

Have diminished ovarian reserve
Have had multiple failed IVF cycles
Have experienced poor embryo quality or fertilization failure
Are over 38 years old and want to use their own eggs instead of donor eggs
Have had miscarriages linked to egg quality issues

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The Cytoplasmic Transfer IVF Journey

Initial Evaluation

Fertility Testing & Imaging

Hysterosalpingography (HSG): An X-ray of the uterus and fallopian tubes to check for blockages or abnormalities
Transvaginal Ultrasound:To examine the uterus and ovaries

Blood tests for hormone levels (AMH, FSH, LH, Estradiol, TSH, Prolactin)

Semen analysis and infectious screening for the male partner

Personalized Stimulation Protocol

Egg Retrieval & Cytoplasmic Transfer

When follicles are mature, a trigger injectionis given 36 hours before retrieval
On retrieval day, the patient must fast (light sedation is used)
A sperm sample is also collected that day (3–5 days abstinence recommended)

Cytoplasmic Transfer Procedure:

Before fertilization, healthy mitochondria from a donor egg are introduced into the patient’s egg
This step energizes the egg, improves quality, and supports fertilization

Fertilization

ICSI (Intracytoplasmic Sperm Injection) is used to inject a single healthy sperm directly into the egg
IMSI (high-magnification sperm selection) may be used to ensure the best sperm is chosen
Patients receive regular updates on embryo progress

Embryo Transfer

Conducted 3–5 days after fertilization
Patient arrives with a full bladderto aid ultrasound-guided transfer
The procedure is painless and quick, and the patient remains awake
After transfer, the coordinator will provide:
A medication sheetwith all post-transfer prescriptions
A support kitwith do’s and don’ts during the 2-week wait

Pregnancy Testing:

A blood test (Beta HCG) is performed 12 days after the transfer to confirm pregnancy

Travel Options for Treatment in Cyprus

Option 1: Full 20-Day Stay

Option 2: Split 10-Day Stay

Ready to Learn More?

Cytoplasmic Transfer is a transformative option for many women who wish to use their own eggs — even after years of disappointment. If you're ready to explore this cutting-edge IVF technique in Cyprus, we’re here to walk with you from the first step to the positive result.

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Cytoplasmic (Mitochondrial) Transfer